Dr. Holbrook Kohrt
Assistant Professor of Medicine (oncology)
Holbrook Kohrt, an Assistant Professor at Stanford Cancer Institute, currently investigates novel therapeutic strategies to enhance anti-tumor immunity, including discovery of checkpoint inhibitors and cancer vaccine strategies. Dr. Kohrt attended Stanford University Medical School as the Baxter Foundation Scholar, Howard Hughes Scholar and American Society of Hematology Research Fellow. During this he developed, validated, and nationally implemented a nomogram for risk prediction in early stage breast cancer. He trained in Internal Medicine at Stanford through the Clinical Investigator Pathway and completed fellowship in Hematology and Oncology at Stanford with a research focus on preclinical models of novel immunomodulatory antibodies. Dr. Kohrt received his PhD in clinical trial design, biostatistics, and tumor immunology from Stanford under mentor Ron Levy with a thesis including the first report of an agonistic monoclonal antibody capable of enhancing the efficacy of tumor-targeting therapeutics. This antibody is now in three phase 1/2 clinical trials, only 3 years since first preclinical research efforts. As faculty at Stanford, Dr. Kohrt is developing novel vaccine strategies which induce tumor antigen specific immunity prior to infusing the donor inoculum and improve graft-versus-tumor reactions without exacerbation of graft-versus-host disease. His studies also include efforts to identify and develop immunomodulatory antibodies targeting immune effector cells subsets, such as natural killer cells, which enhance the anti-tumor activity of tumor-targeting antibodies. Dr. Kohrt is a member of the Cancer Immunotherapy Trials Network. Agents Dr. Kohrt has led in clinical development include IL-15, IL-7, anti-CTLA-4, anti-CD137, anti-PD-1, anti-PD-L1, BTK inhibitors, and HPV as well as WT1-target vaccines. Dr. Kohrt's trials are currently being investigated in the US and three countries internationally.