2012 DNA Vaccine Conference Agenda

Tuesday, December 04, 2012

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5:00pm - 8:00pm

Registration

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Registration Opens

Wednesday, December 05, 2012

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7:30am

Registration Opens

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7:30am - 8:45am

Continental Breakfast in Exhibit/Poster Area

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8:45am - 9:00am

Welcome to DNA Vaccines 2012

Speaker

Dr. David B. Weiner
Professor of Pathology and Laboratory Medicine, University of Pennsylvania

The Future of Malaria Vaccines

Chairs: Ashley Birkett & Niranjan Sardesai

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9:00am - 9:30am

Development of Vaccines to Support Malaria Elimination

Speaker

Ashley Birkett, PhD
Director, Research and Development, PATH Malaria Vaccine Initiative (MVI)

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9:30am - 10:00am

Robust CD8+ T-Cell-Dependent IFN-Gamma Responses Against Restricted Domains on P. Falciparum Antigens Induced by a DNA- Prime-Adenovector Boost Vaccine Regimen are Associated with Protection Against Sporozoite Challenge

Speaker

Martha Sedegah, PhD
Senior Scientist & Director, Clinical Immunology Malaria Program

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10:00am - 10:30am

From the Bench to the Clinic: Development of Viral Vector-Based Blood-Stage Malaria Vaccines

Speaker

Sumi Biswas, DPhil
Group Leader/Post Doctoral Student, The Jenner Institute

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10:30am - 11:00am

Coffee/Networking Breaking in Exhibit/Poster Area

Frontiers in Vaccine Research

Chairs: Matti Sällberg & Martha Sedegah

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11:00am - 11:30am

Therapeutic Indications for DNA Vaccines

Speaker

Tony Ford Hutchinson, PhD
President, Ford-Hutchinson Consulting Ltd

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11:30am - 12:00pm

What is the Role of Therapeutic Vaccination in the Era of Directly Acting Antivirals in the Therapy of Hepatitis C

Speaker

Dr. Matti Sällberg
Professor and Biomedical Scientist, Karolinska Institutet

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12:00pm - 12:30pm

Tuberculosis Vaccines

Speaker

Dr. David Hokey
Senior Director of Immunology & Animal Studies, Aeras

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12:30pm - 1:45pm

Lunch in Exhibit/Poster Area

Cutting-Edge RNA Technologies

Chairs: Peter Liljeström & Andrew Geall

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1:45pm - 2:10pm

DNA/RNA Replicon Vaccines

Speaker

Peter Liljeström, PhD
Professor of Infectious Disease Control, Karolinska Institutet

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2:10pm - 2:35pm

Non-Viral Delivery of Self-Amplifying RNA Vaccines

Speaker

Dr. Andrew Geall
RNA Vaccine Platform Leader, Novartis Vaccines

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2:35pm - 3:00pm

Development of Therapeutic and Prophylactic Vaccines

Speaker

Dr. Karl-Josef Kallen
Principal Scientific Fellow, CureVac, GmbH

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3:00pm - 3:30pm

Coffee/Networking Breaking in Exhibit/Poster Area

Abstract Session

Chairs: Anne De Groot & Amir Khan

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3:30pm - 3:45pm

A Multi-agent Encephalitic Alphavirus DNA Vaccine Delivered by Electroporation Elicits Protective Immunity against Aerosol Challenge with Eastern and Western Equine Encephalitis Viruses in Nonhuman Primates

Speaker

Drew Hannaman
Vice President, Research and Development, Ichor Medical Systems, Inc.

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3:45pm - 4:00pm

Inducing Potent Humoral and Cellular Responses to Multiple Sporozoite and Liver-Stage Malaria Antigens Using pDNA

Speaker

Bernadette Ferraro, PhD, MPH
Postdoctoral Fellow, University of Pennsylvania

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4:00pm - 4:15pm

Development of a Novel DNA Vaccine Strategy for Prevention of Clostridium Difficile Infection

Speaker

Dr. Michele Kutzler
Assistant Professor, Drexel University College of Medicine

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4:15pm - 4:30pm

NF-κB Activation Mediates Tumor-Specific CTL Responses Elicited by DNA Vaccines

Speaker

Maarten Ligtenberg
PhD Candidate, Karolinska Institutet

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4:30pm - 5:30pm

Plenary Roundtable I - Chairs: John Sterling & David Weiner Development and Commercialization of Novel Vaccines

Details

  • Ashley Birkett
  • Tony Ford Hutchinson
  • Niranjan Sardesai
  • Jeffrey Ulmer
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5:30pm - 7:00pm

Cocktail Reception in Exhibit/Poster Area

Thursday, December 06, 2012

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7:30am

Registration Opens

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7:30am - 9:00am

Continental Breakfast in Exhibit/Poster Area

Future Immunogens for Vaccination

Chairs: Jeffrey Ulmer & Allain Rolland

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9:00am - 9:30am

Technologies for the Discovery and Development of New Vaccines

Speaker

Dr. Jeffrey Ulmer
Global Head, External Research, Novartis Vaccines

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9:30am - 10:00am

Intra- and Inter-Cellular Signaling Pathways for DNA Vaccination

Speaker

Ken Ishii, MD, PhD
Project Leader, Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation

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10:00am - 10:30am

Allovectin® Systemic Immunotherapy for Metastatic Melanoma - Phase 3 Study and Pre-licensure Activities

Speaker

Alain Rolland, PhD
Executive Vice President, Product Development, Vical, Inc.

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10:30am - 11:00am

Coffee/Networking Break in Exhibit/Poster Area

Cancer Immune Therapy

Chairs: Richard Heller & Christian Ottensmeier

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11:00am - 11:30am

Targeted Cancer Immune Therapy

Speaker

Christian Ottensmeier, MD, PhD
Professor of Experimental Medicine, University of Southampton, Cancer Sciences

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11:30am - 12:00pm

Gene Electrotransfer for the Enhanced Delivery of Immunomodulating Agents

Speaker

Dr. Richard Heller
Director and Professor, Frank Reidy Research Center for Bioelectrics

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12:00pm - 12:30pm

Clinical Studies of Melanoma Therapy

Speaker

Adil Daud, MD
Clinical Professor of Medicine, University of California, San Francisco

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12:30 - 1:40

Lunch in Exhibit/Poster Area

Technologies and Approaches for Difficult Pathogens

Chairs: Drew Hannaman & Bin Wang

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1:40pm - 2:00pm

The Co-Immunization Strategy Induces Tolerogenic Responses Against Autoimmune Diseases--Its Potential Applications and Mechanisms Behind

Speaker

Bin Wang, PhD
Professor, Fudan University Shanghai Medical College

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2:00pm - 2:20pm

Assessment of Clinical Feasibility For Electroporation Mediated DNA Vaccination in Infectious Disease Applications

Speaker

Drew Hannaman
Vice President, Research and Development, Ichor Medical Systems, Inc.

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2:20pm - 2:40pm

Electroporation-Mediated Genetic Vaccination for Antigen Mapping: Application to Plasmodium Falciparum VAR2CSA Protein

Speaker

Daniel Scherman, PhD
Exceptional Class Director, Centre National de la Recherche Scientifique

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2:40pm - 3:05pm

Modulating T Cell Immunity to Target Cancer: Establishing Effective Responses to Tumor Antigens That are Over-Expressed Self-Proteins

Speaker

Dr. Phil Greenberg
Professor, Medicine, Oncology and Immunology, University of Washington

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3:05pm - 3:30pm

Coffee/Networking Break in Exhibit/Poster Area

HIV

Chairs: Adel Mahmoud & Dennis Burton

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3:30pm - 4:00pm

Dilemma of Immunogen Discovery!

Speaker

Adel Mahmoud, MD, PhD
Lecturer with Rank of Professor in Molecular Biology and Public Policy, Woodrow Wilson School, Princeton

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4:00pm - 4:30pm

A Blueprint for HIV Vaccine Discovery

Speaker

Dr. Dennis Burton
Professor, Department of Immunology and Microbial Science , The Scripps Research Institute

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4:30pm - 5:00pm

Vaccination with HIV DNA and Plasmid IL-12 Delivered via Electroporation Elicits Robust Cellular Immune Responses

Speaker

Spyros Kalams, MD
Associate Professor of Medicine, Vanderbilt University School of Medicine

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5:00pm - 5:40pm

Plotkin Lecture - Immunoprophylaxis by Gene Transfer: Shortcut to an HIV Vaccine

Speaker

Philip Johnson, MD
Chief Scientific Officer and Executive Vice President, The Children's Hospital of Philadelphia

Details

Introduction of speaker by David B. Weiner, PhD
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7:30pm - 10:00pm

Gala - Awards and Roundtable Discussion- The Future of Nucleic Acid Vaccine Technologies - Chairs Margaret Liu & Niranjan Sardesai

Details

  • Robert Bernard
  • Philip Greenberg
  • Joseph Kim
  • Hy Levitsky
  • Adel Mahmoud

Friday, December 07, 2012

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7:30am

Registration Opens

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7:30am - 8:30am

Continental Breakfast in Exhibit/Poster Area

Industry Session

Chairs: Michael Chambers & George Pavlakis

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8:30am - 8:45am

Essential Elements of DNA Vaccine Production for Human Clinical Trials

Speaker

Dorothy Peterson
Vice President of Operations, VGXI, Inc.

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8:45am - 9:00am

Purification of Plasmid DNA on Monolithic Chromatographic Columns

Speaker

Nika Lendero Krajnc, PhD
Chief Research & Development Officer, BIA Separations d.o.o.

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9:00am - 9:15am

Heterologous DNA-Prime/Peptide-Boost Vaccination with Cross-Conserved H1N1 Influenza CD4+ T-cell Epitopes Reduces Viral Load in HLA Transgenic Mice

Speaker

Leonard Moise, PhD
Scientific Director Vaccine Research, EpiVax, Inc.

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9:15am - 9:30am

Expression Kinetic Profiles of Electroporation Enhanced DNA Vaccination Targeted to Different Dermal Compartments

Speaker

Dr. Kate Broderick
Director, Research and Development, Inovio Pharmaceuticals, Inc

Frontiers in Cancer Immune Therapy

Chairs: Hy Levitsky & Mark Bagarazzi

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9:30am - 10:00am

Therapeutic Immunity-from Vaccination to Disease Eradication

Speaker

Hy Levitsky, MD
Head of Cancer Immunology Experimental Medicine, Roche

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10:00am - 10:30am

Immune Therapies for HPV Disease

Speaker

Dr. Cornelia Trimble
Associate Professor of Gynecology and Obstetrics, Johns Hopkins School of Medicine

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10:30am - 11:00am

Coffee/Networking Break in Exhibit/Poster Area

Cancer Frontiers

Chairs: Cornelia Trimble & Mark Selby

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11:00am - 11:30am

Blocking Negative Regulators to Enhance Anti-Tumor Responses

Speaker

Mark Selby, PhD
Director, Bristol Meyers Squibb

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11:30am - 12:00pm

Immunotherapy Directed Against HPV 16/18 Generates Potent Th1 and Cytotoxic Cellular Immune Responses

Speaker

Dr. Mark Bagarazzi
Chief Medical Officer, Inovio Pharmaceuticals

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12:00pm - 12:20pm

DNA-based Immunization Against Endosialin Compromises Tumor Perfusion and Growth without Affecting Normal Angiogenesis

Speaker

Andrea Facciabene, MD, PhD
Research Assistant Professor, University of Pennsylvania

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12:20pm - 1:45pm

Lunch in Exhibit/Poster Area

HIV Technology

Chairs: Shan Lu & Britta Wahren

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1:45pm - 2:05pm

DNA Vaccination 20 Years Later - Elicitation of High Quality Antibody Responses

Speaker

Dr. Shan Lu, MHA
Professor of Medicine, University of Massachusetts Medical School

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2:05pm - 2:25pm

Feasibilities and Present Results on Childhood HIV Immunization

Speaker

Britta Wahren, MD, PhD
Professor, Karolinska Institutet

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2:25pm - 2:45pm

Therapeutic DNA Vaccination Induces Durable Functional Cure in SIV-Infected Rhesus Macaques

Speaker

Deborah Fuller, PhD
Associate Professor, Department of Microbiology, Core Scientist, Washington National Primate Research Center, University of Washington

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2:45pm - 3:05pm

Comparison of Systemic and Mucosal Responses after DNA and Protein Co-Immunization

Speaker

Dr. Barbara Felber
Principal Investigator, NCI,

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3:05pm - 3:30pm

Coffee/Networking Break in Exhibit/Poster Area

Abstract Session

Chairs: Barbara Felber & Deborah Fuller

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3:30pm - 3:45pm

Increasing Breadth and Altering the Immundominance Hierarchy of HIV-1 Gag by a DNA Vaccine Expressing Conserved Elements of p24gag in Immunized Macaques

Speaker

Dr. George Pavlakis
Principal Investigator, Human Retrovirus Section, Vaccine Branch , National Cancer Institute

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3:45pm - 4:00pm

In Vivo Monitoring of Immune Response in Preclinical Trials of Genetic Vaccines

Speaker

Maria Isaguliants, PhD
Senior Researcher, Karolinska Institutet

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4:00pm - 4:15pm

Examining the Safety, Tolerability and Immunogenicity of a DNA-based Influenza Vaccine in the Elderly; A Phase I Study

Speaker

Trina Racine, PhD
Post-doctoral fellow, National Microbiology Laboratory, Public Health Agency of Canada

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4:15pm - 4:30pm

Multivalent Particle-Mediated DNA Vaccine Against Seasonal and Pandemic Influenza Viruses Elicit Strong Antibody Responses in Non-Human Primates

Speaker

Merika Treants
Graduate Student,

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4:30pm - 4:45pm

Characterization of Influenza Virus-Specific T lymphocyte Responses Induced by Gene Gun-Delivered Multivalent DNA Vaccine

Speaker

Jolie Leonard, PhD
Postdoctoral Fellow, University of Washington

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4:45pm - 5:00pm

Conference Summary and Closing Remarks

Speaker

Dr. David B. Weiner
Professor of Pathology and Laboratory Medicine, University of Pennsylvania